What Is Sculptra® Aesthetic Injectable?

Sculptra® Aesthetic is an FDA-approved facial injectable designed to treat signs of facial fat loss (lipoatrophy) associated with aging. It works by stimulating the body’s natural collagen production, gradually restoring volume and reducing the appearance of shallow-to-deep facial wrinkles and folds, particularly nasolabial folds (lines running from the nose to the corners of the mouth).

It is not recommended for use in the eye or lip areas.

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Main Ingredient: Poly-L-Lactic Acid (PLLA)

Sculptra Aesthetic’s active ingredient is poly-L-lactic acid (PLLA), a synthetic, biocompatible, and biodegradable substance that has been safely used in medical applications for over two decades. It is commonly found in absorbable sutures and soft tissue implants. PLLA helps restore facial volume by encouraging collagen regeneration over time.

Benefits of Sculptra Aesthetic

Approved by the U.S. Food and Drug Administration for the treatment of nasolabial folds, Sculptra Aesthetic offers subtle, natural-looking results that develop gradually. Patients often experience smoother, fuller skin with long-lasting effects.

Although not FDA-approved for other areas, the manufacturer, Valeant Aesthetics, notes that Sculptra can also be used for marionette lines (lines around the corners of the mouth) and chin wrinkles.

Because Sculptra contains no animal, human, or bacterial components, allergy testing is not required. Most patients can return to normal activities immediately after treatment, with little to no downtime.

Treatment and Results

Sculptra Aesthetic treatments are typically performed over a series of sessions. Patients may receive up to four injection sessions spaced approximately three weeks apart.

The treatment works by stimulating collagen production in the targeted areas. As collagen builds, it adds volume and smooths wrinkles and folds. Results vary by individual, but in clinical studies, the effects have been shown to last up to two years for most patients.

Side Effects of Sculptra Aesthetic

Most side effects are mild and temporary, typically resolving within a few days. Common side effects at the injection site include:

  • Bleeding
  • Tenderness
  • Discomfort
  • Redness
  • Swelling
  • Bruising

According to the manufacturer, other potential side effects may include small lumps under the skin that are noticeable when pressing on the treated area. In rare cases, larger lumps with delayed onset—sometimes with inflammation or skin discoloration—have also been reported.